Aiguo Han

Aiguo Han

Assistant Professor

Publications

[Google Scholar] | [NCBI]

Peer-Reviewed Journal Papers
Invited Book Chapters
Invited Editorials
Conference Papers

Peer-Reviewed Journal Papers

†Co-first author *Corresponding author

2024

  1. Z. Tian, M. Olmstead, Y. Jing, and A. Han*, “Transcranial phase correction using pulse-echo ultrasound and deep learning: A 2-D numerical study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 71, no. 1, pp. 117–126, 2024.

  2. Y. Wu, V. Barrere, A. Ashir, X. Chen, L. Silva, S. Jerban, A. Han, M. P. Andre, S. B. Shah, and E. Y. Chang*, “High-frequency quantitative ultrasound imaging of human rotator cuff muscles: Assessment of repeatability and reproducibility,” Ultrason. Imaging, vol. 46, no. 1, pp. 56–70, 2024.

2023

  1. B. L. McFarlin*, M. Villegas-Downs, M. Mohammadi, A. Han, D. G. Simpson, W. D. O’Brien, Jr. “Enhanced identification of at-risk women for preterm birth via quantitative ultrasound: A prospective cohort study,” Am. J. Obstet. Gynecol. MFM 00:101250, 2023.

  2. Y. Wu, V. Barrere, A. Han, M. P. Andre, E. Orozco, E. Y. Chang, and S. B. Shah*, “Quantitative evaluation of rat sciatic nerve degeneration using high-frequency ultrasound,” Sci. Rep., vol. 13, pp. 20228, 2023.

  3. B. L. McFarlin, Y. Liu, M. Villegas-Downs, M. Mohammadi, D. G. Simpson, A. Han, and W. D. O’Brien, Jr.*, “Predicting spontaneous pre-term birth risk is improved when quantitative ultrasound data are included with historical clinical data,” Ultrasound Med. Biol. vol. 49, no. 5, pp. 1145–1152, 2023.

  4. K. Nagabhushana, Q. Wang, and A. Han*, “Pulse-echo technique to compensate for laminate membrane transmission loss in phantom-based ultrasonic attenuation coefficient measurements,” J. Ultrasound Med., vol. 42, no. 1, pp. 45–58, 2023.

  5. Y. Wu†, V. Barrere†, A. Han, E. Y. Chang, M. P. Andre, and S. B. Shah*, “Repeatability, reproducibility and sources of variability in the assessment of backscatter coefficient and texture parameters from high-frequency ultrasound acquisitions in human median nerve,” Ultrasound Med. Biol., vol. 49, no. 1, pp. 122–135, 2023.

2010 - 2022 (Prior to joining Virginia Tech)

  1. K. A. Wear*, A. Han, J. M. Rubin, J. Gao, R. Lavarello, G. Cloutier, J. Bamber, and T. Tuthill, “US backscatter for liver fat quantification: An AIUM-RSNA QIBA Pulse-Echo Quantitative Ultrasound Initiative,” Radiology, vol. 305, no. 3, pp. 526–537, 2022.

  2. J. Jung, A. Han, E. Madamba, R. Bettencourt, R. R. Loomba, A. S. Boehringer, M. P. Andre, J. W. Erdman, Jr., W. D. O’Brien, Jr., K. J. Fowler, C. B. Sirlin, and R. Loomba*, “Direct comparison of quantitative US versus controlled attenuation parameter for liver fat assessment using MRI proton density fat fraction as the reference standard in patients suspected of having NAFLD,” Radiology, vol. 304, no. 1, pp. 75–82, 2022. (Featured in an editorial in Radiology.)

  3. X. Chen, M. R. Lowerison, Z. Dong, A. Han, and P. Song*, “Deep learning-based microbubble localization for ultrasound localization microscopy,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 69, no. 4, pp. 1312–1325, 2022.

  4. M. Byra*, A. Han, A. S. Boehringer, Y. N. Zhang, W. D. O’Brien, Jr., J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and M. P. Andre, “Liver fat assessment in multiview sonography using transfer learning with convolutional neural networks,” J. Ultrasound Med., vol. 41, no. 1, pp. 175–184, 2022.

  5. A. Han*, M. Byra, E. Heba, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat with radiofrequency ultrasound data using one-dimensional convolutional neural networks,” Radiology, vol. 295, no. 2, pp. 342–350, 2020. (Featured in an editorial in Radiology.) [code]

  6. A. Han*, Y. N. Zhang, A. S. Boehringer, V. Montes, M. P. Andre, J. W. Erdman, Jr., R. Loomba, M. A. Valasek, C. B. Sirlin, and W. D. O’Brien, Jr., “Assessment of hepatic steatosis in nonalcoholic fatty liver disease using quantitative ultrasound,” Radiology, vol. 295, no. 1, pp. 106–113, 2020.

  7. A. Han*, Y. N. Zhang, A. S. Boehringer, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Inter-platform reproducibility of ultrasonic attenuation and backscatter coefficients in assessing NAFLD,” Eur. Radiol., vol. 29, no. 9, pp. 4699–4708, 2019.

  8. S. Chen, B. L. McFarlin, B. T. Meagher, T. A. Peters, D. G. Simpson, W. D. O’Brien, Jr., and A. Han*, “A phantom-based assessment of repeatability and reproducibility of transvaginal quantitative ultrasound,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 66, no. 9, pp. 1413–1420, 2019.

  9. J. L. Rowles, A. Han, R. J. Miller, J. R. Kelly, C. C. Applegate, M. A. Wallig, W. D. O’Brien, Jr., and J. W. Erdman, Jr.*, “Low fat but not soy protein isolate was an effective intervention to reduce nonalcoholic fatty liver disease progression in C57BL/6J mice: monitored by a novel quantitative ultrasound (QUS) method,” Nutr. Res., vol. 63, pp. 95–105, 2019.

  10. R. J. Miller, A. Han, J. W. Erdman, Jr., M. A. Wallig, and W. D. O’Brien, Jr.*, “Quantitative ultrasound and the pancreas: Demonstration of early detection capability,” J. Ultrasound Med., vol. 38, no. 8, pp. 2093–2102, 2018.

  11. A. Han, Y. Labyed, E. Z. Sy, A. S. Boehringer, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr.*, “Inter-sonographer reproducibility of quantitative ultrasound outcomes and shear wave speed measured in the right lobe of the liver in adults with known or suspected non-alcoholic fatty liver disease,” Eur. Radiol., vol. 28, no. 12, pp. 4992–5000, 2018.

  12. A. Han, M. P. Andre, L. Deiranieh, E. Housman, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr.*, “Repeatability and reproducibility of the ultrasonic attenuation coefficient and backscatter coefficient measured in the right lobe of the liver in adults with known or suspected nonalcoholic fatty liver disease,” J. Ultrasound Med., vol. 37, no. 8, pp. 1913–1927, 2018.

  13. A. Han*, “A method for stereological determination of the structure function from histological sections of isotropic scattering media,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 65, no. 6, pp. 1007–1016, 2018.

  14. P. Muleki-Seya, A. Han, M. P. Andre, J. W. Erdman, Jr., and W. D. O’Brien, Jr.*, “Analysis of two quantitative ultrasound approaches,” Ultrason. Imaging, vol. 40, no. 2, pp. 84–96, 2018.

  15. Y. Zhu*, A. Han, W. D. O’Brien, Jr., M. L. Oelze, and M. F. Insana, “Limitations on estimation of effective scatterer diameters,” J. Acoust. Soc. Am., vol. 142, no. 6, pp. 3677–3690, 2017.

  16. A. G. B. Cruz, A. Han, E. J. Roy, A. B. Guzmán, R. J. Miller, E. A. Driskell, W. D. O’Brien, Jr., and J. L. Shisler*, “Deletion of the K1L gene results in a vaccinia virus that is less pathogenic due to muted innate immune responses, yet still elicits protective immunity,” J. Virol., vol. 91, no. 15, pp. e00542–17, 2017.

  17. J. S. Paige, G. S. Bernstein, E. Heba, E. A. C. Costa, M. Fereirra, T. Wolfson, A. C. Gamst, M. A. Valasek, G. Y. Lin, A. Han, J. W. Erdman, Jr., W. D. O’Brien, Jr., M. P. Andre, R. Loomba, and C. B. Sirlin*, “A pilot comparative study of quantitative ultrasound, conventional ultrasound, and MRI for predicting histology-determined steatosis grade in adult nonalcoholic fatty liver disease,” Am. J. Roentgenol., vol. 208, no. 5, pp. W168–W177, 2017.

  18. A. Han, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr.*, “Repeatability and reproducibility of a clinically based QUS phantom study and methodologies,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 64, no. 1, pp. 218–231, 2017. (Editor’s Selection of Articles - Oct 2017)

  19. A. Han and W. D. O’Brien, Jr.*, “Structure function estimated from histological tissue sections,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 63, no. 9, pp. 1296–1305, 2016.

  20. J. Garcia-Duitama, B. Chayer, A. Han, D. Garcia, M. L. Oelze, and G. Cloutier*, “Experimental application of ultrafast imaging to spectral tissue characterization,” Ultrasound Med. Biol., vol. 41, no. 9, pp. 2506–2519, 2015.

  21. S. C. Lin†, E. Heba†, T. Wolfson, B. Ang, A. Gamst, A. Han, J. W. Erdman, Jr., W. D. O’Brien, Jr., M. P. Andre, C. B. Sirlin, and R. Loomba*, “Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat using a new quantitative ultrasound technique,” Clin. Gastroenterol. Hepatol., vol. 13, no. 7, pp. 1337–1345, 2015.

  22. A. Han and W. D. O’Brien, Jr.*, “Structure function for high-concentration biophantoms of polydisperse scatterer sizes,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 62, no. 2, pp. 303–318, 2015.

  23. A. Han, R. Abuhabsah, R. J. Miller, S. Sarwate, and W. D. O’Brien, Jr.*, “The measurement of ultrasound backscattering from cell pellet biophantoms and tumors ex vivo,” J. Acoust. Soc. Am., vol. 134, no. 1, pp. 686–693, 2013.

  24. A. Han, R. Abuhabsah, J. P. Blue, Jr., S. Sarwate, and W. D. O’Brien, Jr.*, “Ultrasonic backscatter coefficient quantitative estimates from high-concentration Chinese hamster ovary cell pellet biophantoms,” J. Acoust. Soc. Am., vol. 130, no. 6, pp. 4139–4147, 2011.

  25. M. Teisseire, A. Han, R. Abuhabsah, J. P. Blue, Jr., S. Sarwate, and W. D. O’Brien, Jr.*, “Ultrasonic backscatter coefficient quantitative estimates from Chinese hamster ovary cell pellet biophantoms,” J. Acoust. Soc. Am., vol. 128, no. 5, pp. 3175–3180, 2010.

Invited Book Chapters

  1. A. Han, “Extracting quantitative ultrasonic parameters from the backscatter coefficient,” in Quantitative Ultrasound in Soft Tissues (2nd ed.), J. Mamou and M. L. Oelze, Eds. Springer Nature Switzerland AG, 2023, pp. 43-63.

Invited Editorials

  1. A. Han, “Hepatic steatosis assessment: Harnessing the power of integrating multiple quantitative US parameters,” Radiology, vol. 309, no. 1, e232475, 2023.

Conference Papers

  1. P. Muleki-Seya, A. Han, and W. D. O’Brien, Jr., “Evaluation of ultrasound scattering models adapted for two types of scatterers to extract scatterer parameters from cell-pellet biophantoms,” in 2022 IEEE Int. Ultrason. Symp. (IUS), 2022, pp. 1–4.

  2. Y. Wu, L. Lopez, M. P. Andre, R. Loomba, C. B. Sirlin, M. A. Valasek, M. A. Wallig, W. D. O’Brien, Jr., and A. Han, “Liver fat droplet dependency on ultrasound backscatter coefficient in nonalcoholic fatty liver,” in 2020 IEEE Int. Ultrason. Symp. (IUS), 2020, pp. 1–4.

  3. K. Nagabhushana, W. D. O’Brien, Jr., and A. Han, “Technique to compensate for unknown laminate transmission loss in phantom attenuation measurements,” in 2020 IEEE Int. Ultrason. Symp. (IUS), 2020, pp. 1–4.

  4. A. Han, A. S. Boehringer, Y. N. Zhang, V. Montes, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Improved assessment of hepatic steatosis in humans using multi-parametric quantitative ultrasound,” in 2019 IEEE Int. Ultrason. Symp. (IUS), 2019, pp. 1–4.

  5. R. J. Miller, A. Han, L. T. Gates-Tanzer, J. W. Erdman, Jr., J. L. Shisler, M. A. Wallig, and W. D. O’Brien, Jr., “Quantitative ultrasound and the pancreas: Demonstration of early detection capability,” in 2017 IEEE Int. Ultrason. Symp. (IUS), 2017, pp. 1–4.

  6. P. Muleki-Seya, A. Han, M. P. Andre, J. W. Erdman, Jr., and W. D. O’Brien, Jr., “Comparison of quantitative ultrasound parameters for fat content liver detection and monitoring,” in 2017 IEEE Int. Ultrason. Symp. (IUS), 2017, pp. 1–4.

  7. A. Han and W. D. O’Brien, Jr., “Structure function: Theory, ultrasonic measurement, and histology,” in 2015 Int. Ultrason. Symp. (IUS), 2015, pp. 1–4.

  8. A. Han, J. W. Erdman, Jr., D. G. Simpson, M. P. Andre, and W. D. O’Brien, Jr., “Early detection of fatty liver disease in mice via quantitative ultrasound,” in 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2363–2366.

  9. M. P. Andre, A. Han, E. Heba, J. Hooker, R. Loomba, C. B. Sirlin, J. W. Erdman, Jr., and W. D. O’Brien, Jr., “Accurate diagnosis of non-alcoholic fatty liver disease in humans via quantitative ultrasound,” in 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2375–2377.

  10. J. Garcia-Duitama, A. Han, B. Chayer, D. Garcia, M. L. Oelze, and G. Cloutier, “Experimental validation of plane wave imaging using k-space beamforming for spectral characterization of isotropic media,” 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2414–2417.

  11. W. D. O’Brien, Jr., A. Han, and T. Auger, “Quantitative ultrasound from single cells to biophantoms to tumors,” in Conf. Proc. IEEE Eng. Med. Biol. Soc. (EMBS), 2012, pp. 1118–1120.